is a recognized principle in pharmacology in which a drug simply
having increased effects as its dose becomes larger, research
has consistently shown that exceedingly small doses of a substance
will have the opposite effects of large doses. These two phases
of a drug’s action is called ‘Biphasic response of
drugs (1). This pharmacological principle was concurrently discovered
in 1870, by two separate researchers, Hugo Schultz, a conventional
scientist and Rudolf Arndt, a psychiatrist and homoeopath.
working with the fermentation of yeast, they found that some drug
which in material doses acts as toxic agent to the ferment merely
inhibits its activity, when diluted and actually acts as a stimulant,
when still further diluted which had led to the enunciation of
the famous Arndt-Schultz law. Saller and Dr.Boyd repeated the
same study with different medicines at different periods. Saller
used yeast to study the action of Merc cor, Iodine, Bromium and
Salicylic acid and shows that in weak dose these substances increase
the multiplication of yeast, but strong doses kill them.
Boyd, by a series of most scrupulously planned experiments was
able to demonstrate that the rate of activity of diastase is changed
by the addition to the ferment of micro doses of mercuric chloride
in various high potencies from 61x to 71x(2). Following these
experiments, a number of experimental studies in numerous area
of scientific investigation have verified this law (4). Conventional
scientists who are typically unfamiliar with homoeopathic medicines
have performed these studies. They have not tested or even considered
testing the ultra high dilutions commonly used in homoeopathy.
However, their research has consistently shown very significant
effects from such small micro doses that even the researchers
express confusion and surprise.
the 1920s, conventional scientists who tested and verified this
biphasic response termed the phenomenon as ‘Hormesis’
(3). In 1987, the Journal Health Physics devoted a whole issue
to reporting on a conference on Hormesis.Hormesis may be characterized
by a process where by low doses of an otherwise harmful agents
could result in stimulatory or beneficial effects. A biological,
physiological or biochemical response to a drug at a low dose
may completely opposite to that response when a large dose is
research on the Arndt-Schultz law and Hormesis is important for
validating homoeopathic research, because it demonstrate the evidence
for the important biphasic responses and micro dose effects that
specialize homoeopathy. Arndt-Schultz law is the combination of
law of similia and law of minimum dose in homoeopathy and it laid
the scientific foundation for the basic principles of homoeopathy.
A.R.D. Stebbing, ‘Hormesis’:
The stimulation of growth by low levels of inhibitors,’
science of total environment. , 1982,22:213-34,also, Health
Physics. , May 1987.This entire issue was devoted to the increased
effects of low doses.
biological evidence of the activity of high potencies. British
homoeopathic journal, 1954,44:6
M.Oberboum and J.Camber,”
Hormesis: Dose dependent reverse effects of low and very low
doses,” in P.C.Endler and J.Schulte (eds.), ultra high
dilution, Dordrecht: kluwer Academic, 1994.Stebbing.op.cit.
Oberbaum and Camber; Stebbing
op .cit; Health Physics op.cit.