Hahnemann completed the 6th edition of Organon in 1842 while in active
practice in Paris, but the same did not see the light of the day till
1921 long after his death in 1843 for various unavoidable reasons. He
made many changes in the 6th edition, until but the most important of
them are regarding the preparation of homoeopathic medicines in their
mother form and subsequent potencies and also their administration in
patients.
These valuable changes passed unnoticed for some time and were lying
as the hidden treasure of the 6th edition serious studies and diligence
of some stalwarts of homoeopathic profession brought it out. But these
changes didn’t come all on a sudden; they evolved slowly in course
of several years of experiment and observation out of dire necessity.
Even then many advantages are experienced over usefulness of LM potency
we should remember some disadvantages too.

Disadvantages
Medicines must be administered in liquid form so to prevent the decomposition
of water and rectified spirit.
Standard quality of phial and cork are essential to preserve the medicinal
solution for long time.
Repeated administration of a partially indicated medicine may give relief
on the chief complaints of the patients but the patient as a whole does
not improve as the medicine dose does not cover the fundamental cause
and the totality of symptoms.
In simple and uncomplicated chronic disease of dynamic pathology it
is easier to observe the effect of the medicine by administering a single
dose of centesimal potency. But this is not possible with the medicine
of 50- millesimal scale of potency.
The intricacy of the mode of use of the medicine and regulation of
the so-called aggravation, though very mild lead to lack of enthusiasm
amongst many of us.
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